Type 2 Study Reveals Benefits of Tight Blood Sugar Control
The United Kingdom Prospective Diabetes Study (UKPDS) is the largest study on
type 2 diabetes completed to date. UKPDS evaluated whether intensive blood
sugar control results in reduction of complications among those with type 2
Newly diagnosed subjects were randomly put in 2 groups - a conventional group
and an intensive group. The conventional group had a goal of a fasting
blood sugar of less than 270 mg/dl. The intensive group had a goal of a
fasting blood sugar of less than 108 mg/dl and were given oral hypoglycemic
medications or insulin.
The following outlines some of the UKPDS findings.
The American Diabetes Association indicates these findings support the
position that an active, intensive treatment can reduce complications from
diabetes. The UKPDS shows better blood sugar control can reduce
Note: Diabetes treatment and care is specific. Talk to your
doctor about treatment and blood sugar goals that are right for you.
Discuss how you can reduce risk for diabetes related complications.
The American Diabetes Association. Standards of Medical Care for
Patients with Diabetes Mellitus. Diabetes Care, Volume 26, Supplement 1.
Oxford Centre for Diabetes, Endocrinology & Metabolism: Diabetes Trials Unit.
Christine Carlson, MS, RD, BC-ADM, CDE
- The conventional group was able to maintain a median A1c of 7.9% over a 10
year period. The intensive group was able to maintain a median A1c of 7.0%.
- UKPDS found those with better blood sugar control reduced risk of eye
disease due to diabetes by 25% and reduced risk for early kidney disease by 33%.
- For each percentage point reduction in A1c (for example 8% to 7%), there
was a 35% decrease in risk for microvascular complications.
Microvascular complications are those occurring in small blood vessels such
as the nerves, eyes, and kidneys.
- For every percentage point reduction in A1c, there was a 25% decrease in
risk for diabetes related death and an 18% decrease in risk for fatal or
non-fatal heart attack.
- UKPDS found no evidence of a specific elevated blood sugar level in which
onset of complications occur and therefore blood sugar goals should be as
close to normal as possible.
GlucoMenu® Nutrition Director